Circadian Timekeeping Is Disturbed in Rheumatoid Arthritis at Molecular Level
Figure 5
TNF-α increased ARNTL2 and NPAS2, and suppresses PER3 and DBP expression but IL-6 did not.
Relative gene expression over time is displayed. Representative data from one experiment is shown. The experiment was repeated five times using fibroblasts from different OA patients. The time of TNF-α or IL-6 addition is 0 in the graphs.