Circadian Timekeeping Is Disturbed in Rheumatoid Arthritis at Molecular Level
Figure 2
Localization of BMAL1 protein in RA and OA synovium.
Tissue sections were incubated in rabbit anti-BMAL1 (anti-MOP3). In RA (A and B), relatively strong immunoreactivity was detected in the nuclei (arrows) of the immune cells and fibroblasts, but even stronger immunoreactivity was observed in the cytoplasm of the cells (arrowheads). In contrast to RA, BMAL1 protein was localized only in the nuclei (arrows) of OA synovium (C and D). Irrelevant rabbit IgG was used to confirm the specificity of the BMAL1 antibody (E and F). Scale bar 100 µm.