Stimulating β-Cell Regeneration by Combining a GPR119 Agonist with a DPP-IV Inhibitor
Figure 4
(A) Confocal images represent insulin (red) immunostained pancreas sections from diabetic mice treated with vehicle, PSN632408, sitagliptin, or PSN632408 plus sitagliptin.
(B) Quantification of β-cell mass in the pancreases of non-diabetic control mice and diabetic mice with restored normoglycemia after 7 weeks of treatment with PSN632408, sitagliptin, or PSN632408 and sitagliptin combination (3 to 4 mice per group). β-Cell mass was significantly higher in mice treated with PSN632408 and sitagliptin combination than in mice treated with PSN632408 alone or sitagliptin alone (P<0.05).