Investigate Pathogenic Mechanism of TXNDC5 in Rheumatoid Arthritis
Figure 2
Histochemical examination of collagen-induced arthritis in experimental mice.
The tissue structures of the paw (A–C), knee (E–F) and ankle (G–I) were histochemically examined. Synovial hyperplasia and inflammation, cartilage destruction and bone resorption with pannus formation were observed in the arthritic joints of the collagen-treated TXNDC5-Tg mice (n = 5) but not in WT (n = 5) and TXNDC5-Tg mice treated with BSA (n = 5). Single arrow represents synovial membrane, and double arrow indicates joint cartilage. Magnification: 200×.