Chimeric Infectious Bursal Disease Virus-Like Particles as Potent Vaccines for Eradication of Established HPV-16 E7–Dependent Tumors
Figure 5
Therapeutic tumor challenge III.
A) Top, vaccination schedule. Bottom, tumor survival data (n = 7). Black stars correspond to days 0 and +56, when tumor cells (5×105/mouse) were inoculated. Mice vaccinated once (×1, day +9) with VLP-E7 are represented with red (closed) circles. The remaining symbols correspond to the vaccinated mice as indicated in the square in the survival diagram. B) Evolution of tumor size. Values shown are from individual mice in each group, as indicated in each panel. Animals were sacrificed when tumors reached 1 cm3 (blue line). Black stars indicate subcutaneous tumor cell injection days (0 and +56).