N-glycosylation Dictates Proper Processing of Organic Anion Transporting Polypeptide 1B1
Figure 5
Functional analysis of triple glycosylation site mutants.
Cells were incubated with 0.1 μM E-3-S for 2 min at 37°C. Transport function of mutants was expressed as a percentage of the uptake measured in wild-type OATP1B1. The results represent data from three experiments, with triplicate measurements for each mutant. The results shown are means ± S.E. (n = 3). Asterisks indicate values significantly different (p<0.05) from that of wild-type OATP1B1.