Effect of Interleukin 6 Deficiency on Renal Interstitial Fibrosis
Figure 2
Effect of IL-6 deficiency on the accumulation of bone marrow-derived fibroblast precursors in the kidney after UUO.
A. Representative photomicrographs of kidney sections from WT and IL-6 KO mice 5 days after UUO stained for CD11b (red), procollagen I (green), and DAPI (blue). B. Quantitative analysis of CD11b+ and procollagen I+ fibroblasts in the kidney of WT and IL-6 KO mice 5 days after UUO. ** P<0.01 vs WT control, # P>0.05 vs WT-UUO, and ++ P<0.01 vs KO-UUO. n = 4 per group. C. Representative photomicrographs of kidney sections from WT and IL-6 KO mice 1 week after UUO stained for CD11b (red), procollagen I (green), and DAPI (blue). D. Quantitative analysis of CD11b+ and procollagen I+ fibroblasts in the kidney of WT and IL-6 KO mice 1 week after UUO. ** P<0.01 vs WT control, # P>0.05 vs WT-UUO, and ++ P<0.01 vs KO-UUO. n = 5 per group. E. Representative cytometric diagrams showing the effect of IL-6 deficiency on the accumulation of CD11b and collagen I dual positive fibroblasts in the kidney of WT and IL-6 KO mice 1 week after UUO. F. Quantitative analysis of CD11b and collagen I dual positive fibroblasts in the kidney of WT and IL-6 KO mice 1 week after UUO. ** P<0.01 vs WT control, # P>0.05 vs WT UUO, and ++ P<0.01 vs KO UUO. n = 3 per group.