The h-Current in the Substantia Nigra pars Compacta Neurons: A Re-examination
Figure 5
Basic pharmacology of h-current.
A: Blockage by Cs+ (1 mM): current-clamp responses to a repeated hyperpolarizing current step of 300 pA from a holding potential of −60 mV. Note the progressive suppression of the sag after the indicated times of Cs+ application; T 37°C. B: Blockage by ivabradine (10 µM): voltage clamp responses to a repeated hyperpolarizing step to −130 mV from a holding potential of −40 mV at the indicated times of drug application; T 37°C. C: Blockage by ZD7288 (30 µM); holding potential −40 mV, test potentials ranging from −70 to −130 mV; T 27°C, Ba2+0.5 mM present throughout.