Characterization of Shear-Sensitive Genes in the Normal Rat Aorta Identifies Hand2 as a Major Flow-Responsive Transcription Factor
Figure 5
Increased expression of HAND2 and TRPC4, and decreased expression of FGF12 in regions exposed to low WSS.
Immunostaining for HAND2, FGF12 and TRPC4 in low WSS/disturbed (E, G and I, respectively) and high WSS/uniform (F, H and J, respectively) flow regions, respectively. Panel A and B show staining for PECAM1, and panel C and D show staining for vWF in the corresponding regions. Sections are counterstained with Mayer’s hematoxylin. Images are representative of n = 6 animals. WSS: wall shear stress.