Delayed Contrast Extravasation MRI for Depicting Tumor and Non-Tumoral Tissues in Primary and Metastatic Brain Tumors
Figure 7
Contrast-enhanced T1-weighted MRI (A, D, G), enhancement subtraction maps (B, E, H) and rCBV maps (C, F, I) of patients # 6 (A–C), #3 (D–F) and #26 (G–I) are shown. Patient #6 (GBM) shows a blue rim surrounding the surgery site, representing morphologically active tumor, in agreement with high rCBV values in the corresponding rCBV map. Patient #3 (GBM) is a contradicting example, showing a massive lesion dominated by the blue population in the subtraction maps (confirmed by histology to consist of ∼70% morphologically active tumor), in contrast to low rCBV values in the corresponding rCBV map. Patient #26 (breast cancer brain metastases) shows a thin rim of the blue populations in our maps in agreement with a thin rim of increased rCBV values. The advantages of our vessel function maps over rCBV acquired using DSC in means of high resolution, high sensitivity to contrast and minimum sensitivity to susceptibility artifacts can be seen.