Delayed Contrast Extravasation MRI for Depicting Tumor and Non-Tumoral Tissues in Primary and Metastatic Brain Tumors
Figure 2
Histological determination of tumor and non-tumoral components – GBM.
Examples of contrast-enhanced T1-weighted MRI (A–C), enhancement subtraction maps calculated from the 2 and 75 min data (D–F) and H&E stained histological samples of a rapidly growing lesion in patient #1 with newly diagnosed GBM undergoing standard chemoradiation are shown. Data was acquired prior to surgery, 6 months after initiation of treatment. Samples were taken from a mixed blue and red region (A, D, arrows), a blue region (B, E, arrows) and a red region (C, F, arrows). Histological analysis reveals mixed regions of tumor and necrosis (G, magnification×200), hypercellular tumor (H, magnification×400) and radiation necrosis (J, magnification×400), respectively.