Integrated Model of Metabolism and Autoimmune Response in β-Cell Death and Progression to Type 1 Diabetes
Figure 5
Protective pathway and progression to autoimmune diabetes.
(A) Interaction between protective metabolic pathway and autoimmune response. Autoimmune response with stronger intensity leads to higher concentration of metabolite of protective pathway (effective protective pathway) as compared to the autoimmune response with weak intensity (defective protective pathway). (B) Prediction of β-cell mass in disease progressors and in protected non-progressors. The simulation is based on experimental data for NOD mice. Progressors are IAA+ at 8 weeks of age and non-progressors are IAA+ at 8 weeks of age [10]. β-cell loss is slower in the presence of effective protective pathway.