Integrated Model of Metabolism and Autoimmune Response in β-Cell Death and Progression to Type 1 Diabetes
Figure 2
Model predictions of age-dependent glucose profiles in disease progressors and non-progressors and model validation based on prediction of β-cell mass.
(A) Model prediction of glucose levels in autoantibody positive cases. (B) Model prediction of glucose levels in autoantibody positive cases. The profiles are fitted to glucose measurements in NOD mice from [10] which are shown in the same figure. The goodness-of-fit R2 values are 0.83 (IAA+ progessors), 0.55 (IAA+ non-progressors), 0.59 (IAA- progressors) and 0.18 (IAA- non-progressors). Fitting was performed using the fminsearch function in Matlab (Mathworks, Inc., Natick, MA). Because the number of experimental data points is small (17 data points for IAA+ progressors, 30 data points for IAA+ non progressors, 21 data points for IAA- progressors and 31 data points for IAA- non progressors), we fit the trends of data rather than their exact behaviour. (C) Prediction of β-cell mass: model performances with a set of qualitatively estimated parameters for IAA+ progressors case and with and
parameter value taken from [19].