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Acute Toxicity and Gastroprotection Studies of a New Schiff Base Derived Copper (II) Complex against Ethanol-Induced Acute Gastric Lesions in Rats

Figure 5

Effect of the complex on glutathione (GSH), superoxide dismutase (SOD) and nitric oxide (NO) (A,B and C).

Groups 1 to 3 represent the negative control group, the ulcer control group and the reference control group (omeprazole, 20 mg/kg), respectively. The experimental groups received 10, 20, 40 and 80 mg/kg of the complex are presented as groups 4–7, respectively. All values are expressed as mean ± standard error mean. Mean difference is significant at the p<0.05 level (one-way between groups ANOVA with post-hoc analysis). * significant when compared with the group 2. # significant when compared with the group 3.

Figure 5

doi: https://doi.org/10.1371/journal.pone.0051537.g005