Identification of Regions Involved in Substrate Binding and Dimer Stabilization within the Central Domains of Yeast Hsp40 Sis1
Figure 9
Interface contacts between CTDI and CTDII of Sis1, SYS and Ydj1.
The contacts between CTDI and CTDII of the crystallographic model of Sis1 (A and B) and Ydj1 (G and H) were scouted and compared to the chimerical model of the CTD of SYS (D and E) generated by molecular homology modeling (data not shown). Panels C), F) and I) present the amino acids at the interface that make hydrophobic contacts (full line) and electrostatic contacts (dashed lines). Some of the later contacts involve atoms of the peptide bond of the indicated amino acids. Amino acids not indicated are on the surface or turned inwards towards the core of the CTD subdomains.