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Mechanistic and Structural Understanding of Uncompetitive Inhibitors of Caspase-6

Figure 2

Structure of the N-furoyl-phenylalanine screening hit (2) and the optimized analog 3.

Potency values represent the inhibition of caspase-6 cleavage of (VEID)2R110 substrate.

Figure 2

doi: https://doi.org/10.1371/journal.pone.0050864.g002