Screening the Budding Yeast Genome Reveals Unique Factors Affecting K2 Toxin Susceptibility
Figure 4
Gene products involved in K2 susceptibility are highly interconnected within cell.
Physico-functional networks were established with STRING (see Materials and Methods and Figure S2). Gene products are depicted as color-coded nodes, according to cellular processes, and are connected by edges. Color coding is as follows: red, mitochondrion organization & translation; deep purple, proton transport & ATP synthesis; brown, phospholipid transport; orange, ER associated protein catabolism; yellow, cell wall organization & biogenesis; light green, carbohydrate metabolism; dark green, osmosensory signaling; light purple, chromosome organization & gene expression; blue, homeostatic process. Some nodes are connected through intermediates, which were not all represented here for simplification (see Figure S2 for details). A. Mutations leading to increased resistance. B. Mutations leading to increased hypersensitivity.