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Beta-Lapachone, a Modulator of NAD Metabolism, Prevents Health Declines in Aged Mice

Figure 5

βL preserves mitochondria.

(A) Electron microscopy (×15,000 magnification) of skeletal muscle. Scale bar represents 2 µm. (B) Quantification of inter-myofibrillar mitochondria number per 100 µm2 in the skeletal muscles after 10 months treatment (analysis of seven images per mouse, n = 5 per group) (C) Quantitative RT-PCR of genes related to mitochondrial function (n = 4 mice/group). Data represent mRNA levels relative to cyclophilin A. Data represent the mean ± SEM. *P<0.05 versus control.

Figure 5

doi: https://doi.org/10.1371/journal.pone.0047122.g005