Spermine Attenuates the Action of the DNA Intercalator, Actinomycin D, on DNA Binding and the Inhibition of Transcription and DNA Replication
Figure 8
Polyamine depletion enhances the inhibition of cell viability by actinomycin D.
The effects of ACTD at various concentrations on the viability of in (A) HeLa, (B) A549, and (C) MCF7 cells with or without a 24 h pretreatment with 2 µM MGBG. The data represent the mean values ±SDs from three separate experiments (*p<0.05).