Intrahepatic Infiltrating NK and CD8 T Cells Cause Liver Cell Death in Different Phases of Dengue Virus Infection
Figure 3
Intrahepatic infiltrating NK cells cause liver cell death at day 1 after DENV infection.
(A) Liver cryosections collected from mice with or without anti-CXCL10 antibody at day 1 after DENV infection were stained with anti-CD49b antibody. Data are representative of three independent experiments (n = 3 per time point in each experiment). (B) Uninfected and infected mice at day 1 were treated with different volumes of anti-AGM1 antibody. Arrow points to cleaved capase 3. Data presented are representative of four independent experiments (n = 3 per time point in each experiment). (C) Liver cryosections collected from uninfected or infected mice with or without anti-AGM1 were stained with TUNEL reagents. Data are representative of three independent experiments (n = 3 per time point in each experiment).