Synthesis and Antiangiogenic Activity of N-Alkylated Levamisole Derivatives
Figure 7
Test for activation of sirtuin 1 (SIRT1).
The ability of compound 7a to activate SIRT1 mediated deacetylation was tested in a commercially available fluorogenic assay. Resveratrol was used a positive control, although its relevance as a direct activator of sirtuin activity has been called into question recently [59]–[62]. The data represent two individual assays performed in duplicate.