Perlecan Domain V Induces VEGf Secretion in Brain Endothelial Cells through Integrin α5β1 and ERK-Dependent Signaling Pathways
Figure 6
Schematic representation of DV signal transduction, VEGF gene expression, secretion and its subsequent activity at the neurovascular unit.
Proposed model by which DV interaction with the BEC α5β1 integrin results in increased VEGF production and secretion. The use of various antagonists (red lines) is also shown.