Homology Modeling of Dopamine D2 and D3 Receptors: Molecular Dynamics Refinement and Docking Evaluation
Figure 6
Evolution of binding pockets of hD3 and hD2L receptor after model refinement.
Pockets generated by Fpocket server are represented as colored clusters of spheres. Left panels represent hD3 (green ribbons) and right panels represent hD2L (cyan ribbons), before (A, B) and after (C, D) MD simulations. The red circles target the orthosteric binding pocket whereas the black circles highlight the allosteric binding pocket.