Anti-Cancer Activity of a Novel Small Molecule Compound That Simultaneously Activates p53 and Inhibits NF-κB Signaling
Figure 6
Global expression profiling of N-2-responsive genes in A549 cells.
(A) Interaction map of DEGs. Overall network reveals many interesting interactions that may be connected to p53 or NF-κB. The node color represents fold change (green, downregulation; red, upregulation). (B) N-2 up-regulates the mRNA levels of stress response genes (DDIT3, DDIT4, SESN2, and GADD45a) and down-regulates the mRNA level of genes associated with proliferation (PCNA and CCND3). The transcription level of selected genes was confirmed with RT-PCR. * p<0.01, ** p<0.001.