Natural Iminosugar (+)-Lentiginosine Inhibits ATPase and Chaperone Activity of Hsp90
Figure 4
Aggregation kinetics of CS at 43°C determined by light scattering.
The spontaneous aggregation of CS at 43°C (♦) and the aggregation of CS at 43°C in the presence of 0.075 µM Hsp90 (Δ) or of 0.075 µM Hsp90 and 0.3 µM compound 1 (▪), 0.3 µM compound 2 (•), 0.3 compound 3 (□), or 0.3 µM compound 4 (○) are shown.