Quantification of Lung Fibrosis and Emphysema in Mice Using Automated Micro-Computed Tomography
Figure 5
µCT imaging can also quantify lung emphysema in mice.
(A) Representative histological image of an elastase-treated mouse (hematoxylin and eosin staining). (B) End-inspiratory aerated volumes (EEV), calculated by µCT, in elastase (PPE)-induced pulmonary emphysema (ANOVA p<0.0001; PBS versus both 0.25U and 0.5U PPE: * p<0.05, 0.25U versus 0.5U PPE: * p<0.05). (C) Pressure-Volume (PV)-curves of elastase-induced pulmonary emphysema, based on flexiVent measurement (ANOVA p<0.0001; PBS versus both 0.25U and 0.5U PPE: * p<0.05, 0.25U versus 0.5U PPE: * p<0.05).