Presynaptic Selectivity of a Ligand for Serotonin 1A Receptors Revealed by In Vivo PET Assays of Rat Brain
Figure 5
Time course of specific [11C]WAY-100635 binding to 5-HT1A receptors in the hippocampus (top panels) and raphe nucleus (bottom panels) after pretreatments with Wf-516 (A) and pindolol (B) at representative doses.
Data were generated by placing ROIs on different brain structures on the PET images illustrated in Figure 3. Binding was estimated as the difference in radiosignals between target and cerebellar regions, and expressed as the percentage of the injected dose per unit tissue volume (%dose/mL). Bars indicate S.E. (n = 4 and 3 in Wf-516 and pindolol treatment groups, respectively).