Presynaptic Selectivity of a Ligand for Serotonin 1A Receptors Revealed by In Vivo PET Assays of Rat Brain
Figure 4
Time-radioactivity curves for [11C]WAY-100635 in the hippocampus (top panels), raphe nucleus (middle panels) and cerebellum (bottom panels) after pretreatments with Wf-516 (A) and pindolol (B) at representative doses.
Data were generated by placing ROIs on different brain structures on the PET images illustrated in Figure 3. Radiotracer uptake into each region was expressed as a percentage of the injected dose per unit tissue volume (%dose/mL). Bars indicate S.E. (n = 4 and 3 in Wf-516 and pindolol treatment groups, respectively).