Presynaptic Selectivity of a Ligand for Serotonin 1A Receptors Revealed by In Vivo PET Assays of Rat Brain
Figure 3
Representative PET images showing distribution of [11C]WAY-100635 in rat brains after oral administration of Wf-516 and intraperitoneal administration of pindolol.
Each pretreatment drug was repeatedly administered to the same rat at different doses. PET images were generated by summation of dynamic data 60–90 min after intravenous injection of [11C]WAY-100635, and were overlaid on the MRI template displayed in the far left column. Coronal brain sections shown here were obtained at −5.2 mm (top row), −7.8 mm (middle row) and −12.5 mm (bottom row) from the bregma. ROIs were placed on the hippocampus (dotted lines), raphe nucleus (solid lines) and cerebellum (dashed lines).