Presynaptic Selectivity of a Ligand for Serotonin 1A Receptors Revealed by In Vivo PET Assays of Rat Brain
Figure 1
Binding affinities of Wf-516 and pindolol for central 5-HT1A receptors quantified by in vitro ARG.
(A) Representative autoradiograms showing distribution and intensity of [11C]WAY-100635 radiosignals in rat brain sections containing the hippocampus (arrows) and raphe nucleus (arrowhead) and its attenuation by different concentrations of Wf-516 or pindolol. (B) Inhibition curves of [11C]WAY-100635 binding to the hippocampus (closed symbols) and raphe nucleus (open symbols) by Wf-516 (left) and pindolol (right). Bars indicate S.E. (n = 3).