Characterization of Model Peptide Adducts with Reactive Metabolites of Naphthalene by Mass Spectrometry
Figure 4
Depletion of unadducted peptides by metabolites.
Depletion of GRGDSPC (A), DYKDDDDK (B), and DASFHSWG-NH2 (C) by reaction with either NO (naphthalene epoxide) or NQ (1,2-naphthoquinone) at two different ratios of peptide: metabolite, 1∶1 and 1∶10. Depletion of the unadducted peptide was monitored by measuring the peak area of the peptide at each time point.