A New Antifibrotic Target of Ac-SDKP: Inhibition of Myofibroblast Differentiation in Rat Lung with Silicosis
Figure 6
Effect of Ac-SDKP on expression of SRF as analyzed by immunohistochemistry in the rat silicotic model.
SRF-positive immunostaining was only observed in smooth muscle cells in vessels and trachea in control. Notably, there was more positive expression of SRF in silicotic nodules and the area of mesenchyma fibrosis in the silicotic model (4w and 8w). Positive expression of SRF in Ac-SDKP post- and pre-treatment was less than that in the silicotic model.