A New Antifibrotic Target of Ac-SDKP: Inhibition of Myofibroblast Differentiation in Rat Lung with Silicosis
Figure 5
Effect of Ac-SDKP on expression α-SMA as analyzed by immunohistochemistry in the rat silicotic model.
α-SMA-positive immunostaining was only observed in smooth muscle cells in vessels and trachea in control. Notably, there was more positive expression of α-SMA in silicotic nodules and the area of mesenchyma fibrosis in silicotic model (4w and 8w). Positive expression of α-SMA in Ac-SDKP post- and pre-treatment was less than that in the silicotic model.