A New Antifibrotic Target of Ac-SDKP: Inhibition of Myofibroblast Differentiation in Rat Lung with Silicosis
Figure 3
Effect of Ac-SDKP on lung collagen expression in the rat silicotic model.
Compared with control group, the lung collagen content was significantly increased in the rat silicotic model, while Ac-SDKP treatment induced a significant decrease of collagen expression. A) Total collagen content measured by hydroxyproline assay; C4: control 4w group; S4: silicotic model 4w group; C8: control 8w group; S8: silicotic model 8w group; Ac-post: Ac-SDKP post-treatment group; Ac-pre: Ac-SDKP pre-treatment group; B) The tissue extracts were analyzed by Western blot analysis with antibodies against collagen type I and III; C) The collagen type I protein expression measured by Western blot; D) The collagen type III protein expression measured by Western blot.