On the Structure and Function of the Phytoene Desaturase CRTI from Pantoea ananatis, a Membrane-Peripheral and FAD-Dependent Oxidase/Isomerase
Figure 12
Substrate binding site and aligning amino acid residues.
The substrate binding site shows the lowest energy conformations of in silico-docked C18 substrate. The isoalloxazine ring of FAD docks into the same site (Figure S4). The positions of substrate interacting hydrophobic residues are shown in grey (compare Table S2). See the Discussion for the likely role of the charged amino acids.