Metabolomic Profiling Reveals Mitochondrial-Derived Lipid Biomarkers That Drive Obesity-Associated Inflammation
Figure 3
Lipotoxicity and mitochondrial dysfunction induced by CAF diet in muscle.
Aged-matched male rats were fed diets for 15 weeks and tissue was isolated from animals sacrificed after a 6 hour fast. A) Muscle triglyceride levels were doubled in CAF-fed rats compared to SC-fed controls (*p<0.02, n = 4 SC, 5 CAF). B) Acylcarnitines accumulate in muscle of CAF-fed rats compared to SC controls (*p≤0.02). Metabolites measured and tissue isolation as in Figure 1. (n = 8 SC, 9 CAF for B). See Table S4 for full names of metabolites.