Metabolomic Profiling Reveals Mitochondrial-Derived Lipid Biomarkers That Drive Obesity-Associated Inflammation
Figure 2
Serum myristate correlates to Metabolic Syndrome measures: weight gain, HOMA-IR, and blood glucose.
Aged-matched male rats were fed diets for 10 weeks and serum was isolated in 6 hour-fasted rats and metabolites measured as in Figure 1 (n = 8 SC, 9 CAF). A) Serum concentrations of individual NEFAs indicate that of the eight fatty acids measured, seven were significantly elevated in CAF-fed rats versus SC controls. (*p = 0.04, #p = 0.01, ∧p<0.0001). B–D) Serum saturated fatty acid myristic acid (C14∶0) significantly correlated with weight gain (B), HOMA-IR (C) and blood glucose at sacrifice (D).