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Growth Inhibition and Apoptosis Induced by Osthole, A Natural Coumarin, in Hepatocellular Carcinoma

Figure 3

Effects of Osthole on apoptosis of HCC cells.

(A) Induction of apoptosis of SMMC-7721 and Hepa1-6 cells after osthole treatment. SMMC-7721 and Hepa1-6 cells were treated with osthole at doses of 0, 41.0, 84.0, 123.0, 164.0 and 205.0 µM for 48 h. Apoptosis was measured by flow cytometry. (B) Statistical analysis of the percentages of the apoptotic cells. Data shown were representatives of three experiments.

Figure 3

doi: https://doi.org/10.1371/journal.pone.0037865.g003