Secretogranin II; a Protein Increased in the Myocardium and Circulation in Heart Failure with Cardioprotective Properties
Figure 6
The secretogranin II fragment secretoneurin has protective effects during myocardial ischemia and cardiomyocyte stress.
A, Secretoneurin (SN) perfusion reduces infarct size by 30% (upper left) as demonstrated in representative TTC stained images (upper right) after global ischemia in the isolated perfused rat heart. B, Secretoneurin perfusion also improves myocardial function as assessed by LV end-diastolic pressure (LVEDP) after I/R injury. C, Cardiomyocyte apoptosis in vitro after H2O2 exposure was attenuated by secretoneurin stimulation. Cells were extracted from 5 different cell isolations (n = 5 for all groups). D, Short-term stimulation of cardiomyocytes with 10 µg/mL secretoneurin activated protective intracellular pathways as reflected by increased Stat3 and Erk1/2 phosphorylation (n = 5 for all groups). **p<0.001, *p<0.01, # p<0.05.