The Therapeutic effect of Memantine through the Stimulation of Synapse Formation and Dendritic Spine Maturation in Autism and Fragile X Syndrome
Figure 7
Memantine stimulated the formation of inhibitory synapses in Fmr1-KO CGCs.
Representative photomicrographs of labeling of VGAT (arrow) in WT CGCs, KO CGCs and KO CGCs treated with memantine. Green, VGAT; Blue, Hoechst, scale bars, 25 µm. The histogram shows quantification of puncta size using image analysis and ratio of excitatory synapses to inhibitory synapse. WT, n = 23; Fmr1-KO, n = 25; Fmr1-KO+Memantine, n = 25. *p<0.05, **p<0.01.