The Therapeutic effect of Memantine through the Stimulation of Synapse Formation and Dendritic Spine Maturation in Autism and Fragile X Syndrome
Figure 6
Memantine stimulated the formation of total synapses in Fmr1-KO CGCs.
Representative photomicrographs of labeling of Syp (arrow) in WT CGCs, Fmr1-KO CGCs and Fmr1-KO CGCs treated with memantine. Green, Syp; Blue, Hoechst, scale bars, 25 µm. The histogram shows quantification of puncta size using image analysis. WT, n = 23; Fmr1-KO, n = 25; Fmr1-KO+Memantine, n = 26. **p<0.01.