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Isocorydine Inhibits Cell Proliferation in Hepatocellular Carcinoma Cell Lines by Inducing G2/M Cell Cycle Arrest and Apoptosis

Figure 3

ICD treatment causes cells cycle arrest at the G2/M phase.

(A) The cell cycle distribution of Huh7 cells that were treated with various doses of ICD for 18 h. (B) A statistical graph of the cell cycle distribution shown in (A). (C and D) Western blot analysis of G2/M transition-related proteins after ICD treatment of Huh7, SMMC-7721 and PLC/PRF/5 cells for 18 h.

Figure 3

doi: https://doi.org/10.1371/journal.pone.0036808.g003