Functional Evidence of Multidrug Resistance Transporters (MDR) in Rodent Olfactory Epithelium
Figure 8
Comparison of the kinetics of olfactory responses during inhibitor application.
Representative electroolfactogram (EOG) traces from rat in response to the odorant mixture of 10−4 M before and during MDR inhibitor application. EOG traces were normalized to their maximum amplitude and averaged for the comparison of their time course. Inhibitors applied were verapamil at 200 µM, CsA = cyclosporin A at 5 µM, probenecid at 2.5 mM, and MK571 at 25 µM. Each averaged waveform represents the independent assessment from four different animals.