Functional Evidence of Multidrug Resistance Transporters (MDR) in Rodent Olfactory Epithelium
Figure 7
Summary of the modulatory effects of four MDR inhibitors on olfactory response amplitudes.
A: in the rat olfactory septum, B: in the rat turbinate, and C: in the mouse olfactory septum. Bars represent normalized average peak amplitudes. Responses were normalized with respect to control before inhibitor application which was set to unity. The following stimuli were sequentially applied in control condition and in presence of the specified inhibitor: KCl, IBMX, a mixture of odorants (MIX), isoamyl acetate (ISO), and 2,5-dimethyl pyrazine (2,5DP), at the indicated concentrations. The inhibitors tested were verapamil at 200 µM (gray), cyclosporin A at 5 µM (black), probenecid at 2.5 mM, (light green) and MK571 at 25 µM (green). Note that for the mouse (in C) the results for 5 mM probenecid are shown. **p<0.001, * p<0.05.