Mixed Adjuvant Formulations Reveal a New Combination That Elicit Antibody Response Comparable to Freund's Adjuvants
Figure 7
50% Neutralization titer of individual pseudovirus between groups.
For single adjuvant, animals vaccinated with FCA/FIA (groups 1 and 2) have the highest titers against the tier 1A viruses, and low titers against tier 1B. Sequential immunization with different prime-boost combination of Carbopol-971P/974P and MF59 (groups 6–9) performed no better than using FCA/FIA or MF59 alone. By contrast, the combination of Carbopol-971P and MF59 (group 10) conferred significantly higher neutralization titers over all others (p<0.05), particularly against the tier 1B viruses DJ263.8 and SS1196.1.