Apilimod Inhibits the Production of IL-12 and IL-23 and Reduces Dendritic Cell Infiltration in Psoriasis
Figure 7
Cellular phenotype in normal controls and psoriasis patients before and after 70mg QD treatment.
Whole blood cells from normal controls and psoriasis patients were analyzed by cytometry for the cellular phenotype. Results shown are the percentile ranges based on cell counts (cells/µL) of peripheral CD4+ T cells, CD8+ T cells, B cells, monocytes, eosinophils and neutrophils from normal controls (n = 16) and psoriasis patients in 70mg QD cohort (n = 12) at baseline (week 0) and week 12. Plot: bottom line, 10th%; bottom box, 25th%; top box, 75th%; top line, 90th%. *, p < 0.05; **, p <0.01; statistically significant differences between before (week 0) and after (week 12) 70mg QD apilimod treatment in psoriasis patients.