Apilimod Inhibits the Production of IL-12 and IL-23 and Reduces Dendritic Cell Infiltration in Psoriasis
Figure 6
Changes in the expression levels of TH1, TH17, and other inflammatory genes at week 12 in responders and non-responders.
RT-PCR was performed with biopsies obtained from non-lesion skin and psoriatic lesions. Results shown are the percentile range (25th–75th%, medians indicated) of histological responders (n = 11) and non-responders (n = 27) for IL-12/IL-23p40, IL-23p19, K16, IL-8, IL-17, IFN-γ, iNOS and TNF-α. There were 26 non-responders for IL-17, and 10 responders and 23 non-responders for IL-10 in the analysis of the change due to 0 value at baseline. *, p < 0.05; **, p <0.01; statistically significant differences between before (week 0) and after (week 12) apilimod treatment in responder and non-responder groups.