Apilimod Inhibits the Production of IL-12 and IL-23 and Reduces Dendritic Cell Infiltration in Psoriasis
Figure 5
Changes in the expression levels of IL-12/IL-23p40, IL-23p19, and IL-10 at week 2 in 70mg QD apilimod cohort.
RNA was prepared from biopsies obtained from the psoriatic skin lesions at baseline (week 0) and week 2, and RT-PCR was performed for IL-12/IL-23p40 (a), IL-23p19 (b), and IL-10 (c). The expression levels were normalized to house keeping gene, hARP. Results shown are the expression levels of individuals in 70mg QD cohort (n = 11, 3 histological responders, 8 histological non-responders). *, p ≤0.05; **, p ≤0.01; statistically significant differences between baseline and week 2.