Gastrin-Releasing Peptide Signaling Plays a Limited and Subtle Role in Amygdala Physiology and Aversive Memory
Figure 5
GRPR KO animals showed no differences in conditioned tast aversion (CTA) or neophobia.
A) CTA was evoked by pairing a novel taste, saccharin, with a LiCl injection to induce illness the day before testing (LiCl; n = 12 mice per group). Control animals were offered the novel taste saccharin but injected with NaCl (NaCl groups; n = 11 mice per group) or given only water to drink and injected with NaCl the previous day (saccharin naive groups; n = 12 mice per group). B) Attenuation of neophobia and neophobia were assessed by comparing the aversion to saccharin on first exposure (saccharin naive) with the aversion shown by mice that were exposed to saccharin the previous day (NaCl). On successive days the neophobia was attenuated by repeatedly being given the chance to drink saccharin flavored water.