Pseudomonas aeruginosa Overrides the Virulence Inducing Effect of Opioids When It Senses an Abundance of Phosphate
Figure 2
Kappa opioid induces activation of pqsABCDE synergistically with HHQ.
Luminescence normalized to cell density was measured dynamically in the reporter strain ΔPqsA/pqsA::luxCDABE grown in 0.1xTY in the presence of (A) varying doses of U-50,488; (B) varying doses of HHQ; (C) varying doses of U-50,488+200 µM HHQ; and (D) varying doses of PQS.